He has one major flaw that drives me crazy.

他有个大缺点，让我难受发疯。

Previously, online shopping has always had one major flaw: wait.

此前，网上购物一直有一个重大缺陷：等待。

But, according to a new academic paper, there is a major flaw.

但最近有学术研究指出，这一说法很有问题。

Discovering a major flaw in a project doesn't always mean that it ends the project.

发现了项目中的重大缺陷不一定总是意味着项目的终结。