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So the study of PI3K-Akt maybe a new target in searching drug treatment of tumor.
因此,通过对PI3K通路的研究有望寻求肿瘤药物治疗的新靶点。
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AKT inhibitors have been used in trials on cancer patients before but with limited success.
AKT抑制剂以前在癌症患者身上做过实验,但效果有限。
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"This underscores the importance of discovering the origin of active Akt in glioblastomas," he said.
“这突出了发现胶质母细胞瘤中活性Akt蛋白的重要性,”他说。
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Methods the expression of AKT, PTEN had be detected for the specimens of 48 osteosarcoma and 15 exostosis with immunohistochemistry SABC method.
方法采用免疫组织化学SABC法检测48例骨肉瘤、15例骨软骨瘤标本中akt、PTEN表达的阳性细胞。
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Decreased PTEN protein and increased AKT protein might be a marker for the early detection of the occurrence of colorectal cancer in patients with UC.
PTEN蛋白表达的明显降低和AKT蛋白表达的明显增强有可能成为早期监测uc癌变的一个辅助指标。
1. 蛋白激酶 B(PKB)是原癌基因 c-akt 的表达产物,它参与由生长因子激活的经磷脂酰肌醇3-激酶(PI3K)介导的信号转导过程。与许多蛋白激酶相似,PKB 分子具有一特殊的AH/PH 结构域(AH/PH domain),后者能介导信号分子间的相互作用。