The DNA minor groove binders are in a hot research field and most of them are mainly low molecular weight compounds.

以DNA小沟区为靶点的抗肿瘤药物是近年来研究的热点，它们主要是一些小分子化合物。

Some DNA minor groove binders are now in the basic and clinical research phases. The recent progress of DNA minor groove binders are summarized in this brief review.

目前已有多种小沟区结合剂处于基础和临床研究阶段，对近年来DNA小沟区结合剂的研究情况进行简要阐述。

First at the top of the child in front of about 12 refers to the location of the closure will not see the beating, there is a certain degree of closure or minor groove prominent.

宝宝头顶部正前方约一两指的位置，未闭合的会看到跳动，闭合的会有一定的突出或小沟。